The aging mice that made by D-galactose were feed by different concentrations of Rhodopseudomonas palustris and Se-enrich R. palustris. The results showed that Se-enriched R. paalustris had strong capacity to reduce hepatic cells injury. Karyon, mitochondria, endoplasmic reticulum of cells organelle could be renovated and protected. The capacity of hepatic cells organella and anti- oxidation capacity of the aging mice also could be improved.