Objective To investigate the important role and significance of STAT3 gene during the progress of originating and developing of human hepatocellular carcinoma(HCC).Methods Applying Reverse transcriptase-polymerase chain reaction(RT-PCR) to detect the mRNA expression of STAT3,c-myc,p53,survivin and VEGF genes,the protein expression of STAT3 gene were detected by western blot and immunohistochemical method.Results The mRNA expression of STAT3 gene is significant higher in HCC and tissue beside carcinoma than ...
【更新日期】
2008-03-19
【分类号】
R735.7
【正文快照】
原发性肝癌是我国最常见的恶性肿瘤之一,近年来死亡率增加了41·17%,已成为我国居第二位的肿瘤[1]。肝癌的发生是一个多基因参与,通过不同基因在不同时相的差异表达进行调控的复杂过程[2]。STAT3是转录信号传导子与激活子家族(signal trans-ducers and activators of transcrip
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