Objective To study the genotype of swines isolated from humans and their relationships with hepatitis E virus (HEV) in the rural areas of southern China. Methods Specimens collected from normal people with HEV-IgM positive, acute hepatitis E patients and from swine in the same area were detected for HEV RNA using RT-nPCR with ORF2 primers. The positive PCR products were cloned and sequenced. Results 13 out of the 132 samples from swine stool, 4 of 26 HEV-IgM positive sera of normal people and 1 of 4 acute h...