Aim To investigate the immunomdulatory effects of total flavones of oldenlandia diffusa willd (FOD).Methods In immunosuppressed mice induced by cyclophosphamide, IgM production,proliferation of T and B lymphocytes, levels of IL-2 and INF-γ in serum were used to study the specific immunity of FOD. White blood cell count of mice suppressed by cyclophosphamide and cytarabine was used to observe the non-specific immunity of FOD.Results FOD(60 (mg·kg~(-1))) enhanced IgM production in (immunosup-)pressed mice...