The circadian rhythm depicts a basic feature of life.Discovery of the controlling mechanisms of circadian rhythm will benefit the recognition of the nature of life,life adaptation to environment and health.Clock gene generates circadian rhythms by the core transcription-translation-based autoregulatory feedback loops.The rhythm is coupled and amplified,and spreads into the whole brain and to all the peripheral organs containing local rhythms. In living organisms,circadian rhythm associates with genes,organs...