Objective: To investigate the influence of the level of sex hormone wit h postmenopausal osteoporosis women. Methods: The levels of est rogen(E_2) and testosterone(T) were determined in patients with postmenopau sal osteoporosis and in controls. The results were analyzed with SPSS. R esults: The levels of E_2 and T in patients were significantly low er than the levels in controls(P<0.05). Conclusion: The ch anges of sex hormone might be the risk factor for the postmenopausal osteoporosi s.