Objective:To explore the changes in rabbit endothelin-1 induced by alcoholism.Methods:24 rabbits were chosen and divided into two groups randomly.In experimental group wine containing 50% of alcohol at dosage of 8mL/(kg·d) was given,and the same dose of NS for controls by pouring into stomach with a plastic tube for 6 months and to observe the changes of ET-1,superoxide dismutase(SOD),malondialdehyde(MDA) in plasma in 1-6 months.Results:In 1-3 months,the content of ET-1 and MDA did not change significantly...