OBJECTIVE To prepare new anti-hepatitis B virus medcine “Huaiqi fungal substance ?”. METHODS Bi-directional fementation engineering was applied. RESULTS Huaiqi fungal substance ? was obtained from the fermentative composition of Huaier fungal and Huangqi. The extract of Huaiqi fungal substance ? showed effects of immunity promotion, anti-virus and liver protection. CONCLUSION The pharmacological actions of the property of medicinal fungal substance suggested that the bi-directional fementation engine...