Computational Fluid Dynamics(CFD) provides a method for investigating the complex fluid field in mechanically stirred tank reactors.To introduce the history and progress in developing CFD simulations,by focusing on the evaluation of different CFD methods for modeling stirred tanks,i.e.the Impeller Boundary Condition (IBC),InnerOuter Method (IO),MultiReference Frame (MRF) and Sliding Grid (SG).Based on the review of previous study,the direction of further work on CFD stimulations in stirred tanks is prov...