OBJECTIVE To change the simple cyproheptadine oiltment to compound cyproheptadine cremor for improving clinical efficiency.METHODS To add the constituents of dexamethasone and menthol into the preperation, preparing it to O/W cremor.RESULTS Compound cyproheptadine cremor the new preperation has better curative effect to treat varied dermatologie indications.CONCLUSION The prescription drsign is reasonable, The preparing technology it simple and the clinical application is more effective.