Objective:To investigate the effect of the complex of epidermal growth factor (EGF) and collagen sponge (CS) on reparative dentin formation in vivo.Methods:EGF absorbed onto CS was applied as a direct pulp capping medication in minipig teeth.Calcium hydroxide paste served as control.Samples from both treatment regimens were collected 2,4,12 weeks respectively after surgery and evaluated by histopathological method.Results:Treated with EGF/CS,dental pulp presented partial reparative dentin formation with odo...