Lactate dehydrogenase C4 isozyme has been widely studied as the sperm specific antigen in the research of the contraceptive vaccine. Developmental and testis specific expression of the LDH C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH C gene transcription. The strategy is to induce antibodies in the female reproductive tra...
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