Objective:To observe the efficacy of three therapeutic regimens for perimenopausal women with depression.Methods:A total of 120 perimenopausal women with depressive disorder were randomly divided into 3 groups:group A,B and C received estrogen/progestogen treatment,psychotherapy/fluoxetin and psychotherapy/fluoxetin plus estrogen/progestogen treatment,respectively.Clinical improvement of depressive symptoms was assessed with the Hamilton depression rating scale (HDRS) at baseline and at endpoint of treatmen...