Objective To study the hormone variation in the serum of climacteric women.Methods The levels of FSH?LH?E 2?T?T 3?T 4 and BGP in 55 serum samples of climacteric women were measured, then compared with 50 control samples. Results After statistic andlysis it was found that there existed significant difference ( P <0.01) in the level of FSH?LH?E 2 and T 4 between two groups.Conclusion The measurements of FSH?LH?E 2 and T 4 in the serum have important value for climacteric women.