The purpose of this investigation was to study possible different effects of acupuncture at Zu Sanli on the changes in subcutaneous blood flow at the points along with and outside of meridian. Advanced Laser Doppler flowmeter was used to measure blood flow at 4 points around Zu Sanli and at distal two point along with meridian for 19 normal subjects. The results showed that the increase in subcutaneous blood flow was significant at the points along with meridian, but was not significant at the point outside...