To study the mechanism of the brain injury due to noise, Verapamil hydrochloride (VH) was injected in rats. c fos oncogene expression was less in the animals of VH group compared with that of the placebo group ( P <0.01). The possible mechanism of the VH for the prevention and protection of brain injury was also investigated. The results suggested that the VH was helpfal in the prevention of psychological stress and secondarily induced psychosomatic disorders.