PURPOSE To study the mechanism of selective uptake of high density lipoprotein-2 (HDL2)-CE by hepatic cells. METHODS TO measuse the cell-associated, endocytic and released fluorecence strength (FS) after rat hepatic sinusoidal cells were inucubated with FITC-ApoE-free-HDL2. RESULTS After the cells were incubated with FITC-ApoE-free HDL2 at 37 ℃ for 3 h, the cell- associated fluorescence strength (FS) and endocytic FS were 8.89± 0.87 and 5.35± 0.69 (x± s, n= 2) respectively. The cell-released TCA-precipitabl...