The researches on pathogenic mechanism of non-host specific toxins (NHSTs)have made a greal progress recently. The pathogenic mechanism, especially their primary action site to bost plants of some NHSTs which produced by Fusarium genus.Helminthosporium sativum. and Verticillium dahliae and so on have been reviewed in this paper. It is conclusion that these NHSTs also play a very important roles in their pathogenesis respectively.