Primary intrahepato-carcinoma(PIC)is a rare type human pri-mary hepatic carcinoma that both incidence and mortality are high in china.It was re-ported that the PIC might be caused by clonorchis sinensis. Twenty sample of this tu-mor and their surrounding liver tissues were collected from patients in Xian area forexamination of the presence of HBV antigens by using immunohistochemical methods.It was found that l7 cases (85%)showed positive response with the HBV antigens.Theincidence of HBxAg expression was e...