Female Sprague Dawley rats,at the age of 3 month were subjected to bilateral ovariectomy so as to set up an animal model for post-menopausal osteoporosis study . All rats were sacrificed at 7 weeks postovarectomy and their proximal tibiae were processed undecalcified for quantitative
bone histomorphometry study with stereological method. In comparison to sham operated
control rats, the proximal tibia of ovariectomized rats were characterized by significant decreased in cancellous bone volu...