Our department has reported that total alkaloid of Peganum harmala (TAH) possessed antitumor activities in vitro and in vivo.The ultrastructures of reticulum-cell sarcoma L2 cells were remarkably destructed under electron microscope by theadmini stration of TAH to the tumor-bearing mice. Rough endoplasmic reticulum, mitochondria, cell membrane, nuclear membrane, and chromatin were damaged by TAH. The presence of a lot of vacuoles in cytoplasm, karyopyknosis and muclear dissolution indicated that cells had n...
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