In this research, histopathology of the cerebral cortex was studied in 34 eases of mental retardation, and ultrastucture of the cerebral cortex was observed in 8 cases of them. The main pathological changes of the cerebral cortex in these patients inelude: the abnormalities of the cortical architecture; the irregular arrangement, degeneration, shrinkage and loss of neurons; and the lesions of neurofibrils and myelin, etc. From the above-mentioned, we consider that the pathogensis of mental retardation may b...