Protein tyrosine phosphatases (PTPs), in coordination with protein tyrosine kinases (PTKs), are crucial control mechanism in signal transduction pathways. Defective or inappropriate regulation of PTPs leads to abnormal physiological processes, including cancers, Alzheimer disease, immunodeficiency and diabetes. PTPs are therefore emerged as important targets of related disease. PTPs inhibitors especially the specific PTPs inhibitors toward individual PTP attract great interest, which are expected to be uniq...
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