Mutations are changes in the DNA sequences and include many types, including substitutions, Insertions&Deletions, amplifications, etc. Mutations can be roughly classified into natural mutations, random induced mutations and site-directed induced mutations. In forward genetics, researchers start with a mutation phenotype from natural mutations or random mutagenesis experiments and work toward identifying the mutated genes. In reverse genetics, based on the large scale of genome sequencing, researchers can us...
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