Lack of obvious early symptoms, most of the patients are already in advanced stage with a poor prognosis when they are diagnosed as a esophageal carcinom (EC); and overall surgical 5 years survival rate remains poor at 28%-31.6%. However, surgical treatments for early stage EC increase 5 years survival rate up to 90%. Early diagnosis of EC still is a tickler because of unclear cause, indefinite pathogenesis and absence of sensitive effective early stage biological diagnostic criteria or method. Therefore, e...
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