Background and objectives:
The rapid increased incidence of Diabetic nephropathy(DN)has become the important reason of the rising incidence of End stage ranal disesae(ESRD).Tubulointerstitial lesion is an essential pathological basis in Diabetic nephroapthy.The basic pathological character of which is excessive extracellular matrix(ECM)accumulation in the renal interstitium.It is considered that the renal interstitial ECM is mainly secreted by the myofibroblast(MyoF).Researches have shown that tub...