Small Interfering RNA (siRNA) Targeting VEGF Inhibits Initial A549 Tumor Growth in a Xenograft Murine Model and Angiogenesis Induced by A549 Cell on CAM Assays
Background:
Antiangiogenic therapy has emerged as an important concept in the treatment of solid tumors, including non-small cell lung cancer (NSCLC). Vascular endothelial growth factor (VEGF) represents an important therapeutic target, as it is the primary mediator of angiogenesis and is induced by multiple tumor-relevant stimuli. Although antivascular strategy that targets the endothelial cells of the host was shown to be very efficient at reducing tumor growth and was not expected to trigger tu...
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