Alzheimer’s disease (AD) is an age-related neuro-degenerative disease, characterized by progressive disorder with cognitive and memory decline. Many approaches have been undertaken to understand AD, but the heterogeneity of the etiologic factors makes it difficult to define the most important factor determining the onset and progression of the disease. Until now, AD is considered to be multi-etiopathogenisis disease. It is difficult to find a good way for cure of AD. But the change of cholinerg...