In mammals, testosterone synthesized by testis interstitial tissue play an important role in the physiological procedures such as malization of embryo development, production of sperm, male sexual behavior and male sex gland development. On physiological condition, Leydig cell steroidogenesis is modulated by LH/hCG, some growth factors and cytokines. Glucose is essential for Leydig cell steroidogenesis and glucose transporters (GLUTs) play a key role in the transport of glucose into the cells. However, ther...