Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor prognosis. It causes nearly 1 million deaths annually worldwide. But only a minority of patients is eligible for surgical therapies due to advanced tumors or extrahepatic diseases at primary diagnosis. Recently, the methods of gene delivery are gradually developing and have made great progresses. So the gene therapy of HCC is a hot spot of the biology and clinic medical currently. Suicide gene therapy can be envisioned as a powe...