The author put forward the hypothesis of brain- intestinal connection for the first time in a scientific attitude and rich stuff , and discussing the connective pathology from deep administrative levels and extensive aspect. According as the theory base of the NEIJING and SHANG HAN LUN , the article discuss the forming gist of the hypothesis. Those are bases of the hypothesis of discovering of brain gut peptide, the neural gastroenterology and the clinical report on the relationship of brain-intestinal dise...