The Feasibility and Mechanism Study on the Treatment of Acute Pancreatitis by Inducing Acinar Cell Apoptosis with Effective Ingredient of Chinese Anti-cancer Medicine
[Objective] To investigate the relationship between severity of acute pancreatitis and apoptosis of acinar cells. [Methods] Using intrapancreatobiliary duct injection of different doses sodium deoxycholate, the acute edematous pancreatitis, acute moderate necrotic pancreatitis, and acute severe necrotic pancreatitis model were established in Wistar rats. The apoptotic ratio of acinar cell was then determined by using methods of in situ end labeling (TUNEL), and the pancreatic wet weight, volume o...