Gastroesophageal reflux disease(GERD) is a common condition. Reflux leads to not
only symptoms but also injuries to esophageal tissue which cause reflux esophagitis(RE)
and some severe complications such as Barrett's esophagus(BE) and esophageal
adenocarcinoma (EA). The incidences of BE and EA have seen huge increases over the
past several decades, but etiology and pathogenesis of these conditions remain unclear.
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