Endothelin- 1 is produced by Sertoh Cells in testis and stimulates testosterone
secretion by Leydtg cells as a paracrine factor The aim of the present study is to find
the signal cascade of ET-1 on Leydig cells and effects of ET-1 on testosterone
synthesis pathway
Methods Part 1 Purified rat Leydig cells were exposure to a senes of
concentration of El-i (0.01-100ng/ml) an...