Annexin Ⅰ belongs to the annexins protein superfamily that comprises a multigene family of Ca 2+ and phospholipid binding proteins. Annexins consist of a conserved C terminal or core domain that confers Ca 2+ dependent phospholipid binding and an N terminal domain that is variable in sequences and length and responsible for the specific properties of each annexin. Annexin Ⅰ is one of the structurally related,calcium dependent,phospholipid binding proteins that have been implicated in diverse ...