The Study on a New Bcr/Abl-independent Regulating Mechanism in CML Cells That is Mediated by Abnormal Activation of C-Myc in a Post-transcriptional Manner
Objectives:Chronic myeloid leukemia is a malignant clone disease of hematopoietic stem cells that is caused by the Bcr-Abl fusion gene. In view of the constitutively active Bcr/Abl tyrosine kinase, tyrosine kinase inhibitors(TKI) as first-line treatment for CML now have achieved a huge success. But persistent existence of the minimal residual disease(MRD), recurrence of approximately 30 percent patients after drug withdrawal, drug resistance and poor effect on the blastic phase of CMLpatients have become th...
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