研究目的大量研究表明,中医药在治疗慢性乙型病毒性肝炎(Chronic Viral Hepatitis B,CHB)方面有着独特优势。补肾清毒法源于中医伏气理论“肾虚疫毒内伏肝血”。通过检测补肾清毒法治疗CHB患者前后外周血HBcAg18-27表位特异性细胞毒性T淋巴细胞(cytotoxic T lymphocyte, CTL)的数量和功能,探讨补肾清毒法对CHB患者外周血特异性CTL的影响,部分阐明补肾清毒法抗HBV可能的作用靶点和免疫活化机制,探析慢性乙型肝炎肾虚邪伏理论的现代科学内涵,为补肾清毒法治疗慢性乙型肝炎提供较为全面的科学依据。研究方法1.收集广州中医药大学第一附属医院门诊随访的CHB患者,应用HLA-A2作为过筛指标,经流式细胞术直接荧光免疫法筛选HLA-A2阳性CHB患者共32例,所有入选的HLA-A2阳性CHB患者随机分为西药组15例和中西药组17例。另设10例HLA-A2阳性健康献血者为正常对照组。西药组予拉米夫定治疗,中西药组在拉米夫定治疗基础上加用补肾清毒法。2.采集正常组、中西药组、西药组入组时和治疗6个月后外周静脉血20ml,用密度梯度离心法分离得到外周血单个核细胞(PBMC),并...
【英文摘要】
ObjectiveA large number of studies show that traditional Chinese medicine has a unique advantage in the treatment of Chronic Hepatitis B (CHB). To detect and investigate the peripheral blood HBcAg18-27 table specific cytotoxic T lymphocyte (CTL) number and function in patients with CHB by the treatment of Nourishing Kidney and Eliminating Toxicity, parts clarify Nourishing Kidney and Eliminating Toxicity anti HBV possible target point and immune activation mechanism, and provide more comprehensive scientifi...