目的:失眠被定义为睡眠潜伏期延长、睡眠维持困难、醒后无恢复感或睡眠质量差,并伴有日间功能损害,如警觉性降低、乏力、疲劳、烦躁不安等症状。原发性失眠(Primary Insomnia,PI)以单纯的失眠症状为主,排除了物质、精神疾病及躯体疾病引起的失眠。失眠的病理生理机制仍不清楚,多数学者认为过度觉醒是导致失眠的核心。大量研究表明失眠患者存在皮层的过度觉醒,但对其大脑信息加工的研究相对较少,且前注意加工存在争议。习惯性短睡者(Habitual Short Sleepers,SS)是指习惯性睡眠时间少于6小时的健康人。目前对该类人群的关注相对较少,已有研究表明其新异刺激加工异常。本课题通过事件相关电位(Event-related potentials,ERP)的失匹配负波(Mismatch negativity,MMN)和P3a成分,在被动注意任务条件下,探讨PI患者及SS新异刺激的前注意及注意朝向反应加工是否异常,以及PI患者新异刺激加工的MMN、P3a波幅与其过度觉醒是否相关。方法:本研究包括23例原发性失眠患者(PI)、10例习惯性短睡者(SS)及20例正常对照者(Good Sleepers,GS),三组被...
【英文摘要】
Objective:Insomnia is defined as a complaint of prolonged sleep latency,difficulties in maintaining sleep,the experience of non-refreshing or poor sleep coupled with impariments of daytime functioning,including reduced alertness,fatigue,exhaustion,dysphoria and other symptoms.Primary insomnia(PI)is the insomnia excluding other diseases or substance misuse.The pathophysiological mechanism of insomnia is still unknown.Most scholars believe that hyperarousal is crucial for causing insomnia,but relatively littl...