Objective:Protein arginine methyltransferase1(PRMT1) catalyzes a large proportion of arginine methylation in cells.PRMT1plays important roles in the development and differentiation of neurons. Hirschsprung disease (HD) is characterized by the absence of ganglion cells in distal gut. In this study,we will detect the PRMT1expression in the colon segments from HD patients and control group. We will study the pathogenesis of HD.
Methods:Tissues samples were obtained from forty patients (twenty HD patients a...