NF-κB signaling pathway is one of more thorough research to the signaling known, involved in almost all of the tumorigenesis processes, including cell proliferation, apoptosis, angiogenesis and so on. At present the NF-κB signaling pathway has become hot spots for the malignant tumor of the drugs treatment. Lycorine, a natural alkaloid derived from the plant Amarylidaceae, have been report to exhibit various biological effects on tumor cells. However the mechanism of action remains unclear.Here, our study w...