In recent years, an increasing number of peptide and protein drugs have been playing play an important role in the diagnosis, treatment or prevention of disease as a vaccine. Octreotide was a synthetic octapeptide derivatives, which was therapeutical for the acromegaly and stomach intestinal pancreatic endocrine tumors. The maketed microspheres of octreotide acetate for injection use were prepared with glucose PLGA copolymer (GLU-PLGA). In this paper, the straight-chain PLGA was employed to prepare microsph...