5-Fluorouracil(5-Fu)is a pyrimidine analog class antimetabolite which was widely used alone or in combination chemotherapy regimens.But its use had been limited by its systemic toxicities,which mainly exhibited in hematologic side effects and severe disturbance in bone marrow.After intravenous injection of 5-Fu solution,it was rapidly distributed and eliminated with an apparent terminal half-life of 5-10 min.5-Fu was poorly absorbed after oral administration with extremely variable bioavailability.These dis...