[Objective] Study on the effect of metformin on the intestinal flora, constipation or diarrhea adverse reaction of metformin induced with flora imbalance related. Decoction of Four Mild Drugs on metformin induced dysbacteriosis caused the moderating effect of constipation or diarrhea.
[Method] The general situations of mice were observed; selective culture viable count; feces light microscopy; ileum pathological detection; immune detection; fluorescence in situ hybridization (FISH) for detecting method....