Proteasome is a kind of many catalytic sites protease holocomplex, which isresponsible for the most of the protein degradation in cells. By regulating degradationof damaged or misfolded proteins, proteasome regulates the cellular process, such asthe cell cycle, DNA repair, apoptosis, signal transduction and immune response andso on. The most common form of proteasome is26S proteasome, which consists of20S core particles and proteasome activators. In the effect of proteasome activator,protein substrates turn...
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