Previous studies in our group on a sea anemone-derived fungus Cochlioboluslunatus (TA26-46) led to the isolation of a series of14-nembered resorcylic acidlactones. These metabolites with novel strucures also have diverse bioactivities, suchas antifouling activities against the larvae of Balanus amphtrite and antifungalactivities against different fungal strains. Present study maily focused on the influenceof epigenetic modifiers on C. lunatus (TA26-46). We tried to improve the diversity ofthe secondary meta...