Oleanolic acid is a naturally compound distributed widely in plants all over the world and exhibit many biological activities such as anti-tumor, anti-HIV, liver-protection. However, the drug efficacy of Oleanolic acid is severely limited by its poor solubilities in aqueous systems. Preformulation investigations are designed to improve solubility of Oleanolic acid.
This paper report that polymorph screening of Oleanolic acid was carried out by way of suspension equilibration in 13 solvents. Cooling meth...