目的(1)检验5-羟色胺转运体基因启动子区域连锁多态性(5-HTTLPR)对青少年抑郁症状的影响;(2)检验5-HTTLPR与应激性生活事件的交互效应对抑郁症状的预测作用。
方法随机抽取湖南省长沙市某所高中的252名高一年级学生,并进行为期2年共9次的追踪研究。初次测评时,分别用流调中心用抑郁量表(Center for Epidemiological Studies Depression Scale, CES-D)和青少年生活事件问卷(Adolescent Life Events Questionnaire, ALEQ)评估被试的抑郁症状和生活事件,并抽取5mL静脉血以提取DNA和鉴定5-HTTLPR基因型。初测后的2年中,每隔3个月对所有被试的抑郁症状和生活事件进行追踪评估,共8次追踪。运用多层线性模型(Hierarchical Linear Model, HLM)对收集的数据进行统计分析。
结果多层线性模型分析显示:(1)生活事件对男性和女性的抑郁症状均有显著预测作用(男性:β=0.14,p<0.0001;女性:β=0.13,p<0.0001);(2)5-HTTLPR对男性和女性的抑郁症状...
【英文摘要】
Object (1) To investigate whether Serotonin Transporter Gene Promoter Region Polymorphism (5-HTTLPR) is directly associated with depressive symptoms of adolescents:(2) To investigate interaction between5-HTTLPR and stressful life events in predicting depressive symptoms.
Methods A total of252students were selected randomly from a public high school in Changsha and were conducted9times follow-up assessments during2years. At initial assessment, all the participants completed Center for Epidemiological Stu...