The Modeling of Zebrafish Endotoxic Inflammation and Use of It as a Screening Method to Assess Anti-endotoxic Properties of the Active Component of Traditional Chinese Medicine
Background
Endotoxin (Lipopolysaccharide, LPS) is the major constituent of the outer membrane of all gram-negative bacteria. LPS directly or indirectly elicits many pathophysiological processes in animals, such as metabolic changes, fever, and in extreme cases disseminated intravascular coagulation, multiple organ dysfunction syndrome (MODS), endotoxic shock, and death. Nowaday, there are no effective or specific treatments for systemic inflammatory response syndrome (SIRS) or MODS which triggered by en...
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