Intraconazole solid dispersion was prepared by supercritical CO2 method to improve the dissolution and bioavailability of intraconazole which is poorly water soluble.
Methods of content assay, in-vitro release test and relative substances detection were respectively carried out by UV spectrophotography. The method had good linearity, sufficient recovery and good accuracy. The RSD of intraday and interday precision are lower than 2%.
Using dissolution in vitro of intraconazole as index, orthogonal ex...