Nimodipine solid dispersion was prepared by supercritical CO_2 method to improve the dissolution and bioavailability of nimodipine that is poorly water soluble.
Methods of content assay and in-vitro release test (UV spectrophotography) and relative substances detection (HPLC) were respectively carried out. All methods had good linearity, sufficient recovery and good accuracy. The RSD of intraday and interday precision are lower than 2%
Using dissolution in vitro of nimodipine as index, orthogonal ex...